Anti-CPEB1 Antibody (CAB5913)
- SKU:
- CAB5913
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-CPEB1 Antibody |
| Antibody SKU: | CAB5913 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-561 of human CPEB1 (NP_085097.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, K-562, Mouse brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-561 of human CPEB1 (NP_085097.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HRQA AAVN EATC TWSG QLPP RNYK NPIY SCKV FLGG VPWD ITEA GLVN TFRV FGSL SVEW PGKD GKHP RCPP KGYV YLVF ELEK SVRS LLQA CSHD PLSP DGLS EYYF KMSS RRMR CKEV QVIP WVLA DSNF VRSP SQRL DPSR TVFV GALH GMLN AEAL AAIL NDLF GGVV YAGI DTDK HKYP IGSG RVTF NNQR SYLK AVSA AFVE IKTT KFTK KVQI DPYL EDSL CHIC SSQP GPFF CRDQ VCFK YFCR SCWH WRHS MEGL RHHS PLMR NQKN RDSS |
| Gene ID: | 64506 |
| Uniprot: | Q9BZB8 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, Cytoplasmic granule, Membrane, P-body, dendrite, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 53kDa/54kDa/62kDa |
| Observed MW: | 62kDa |
| Synonyms: | CPEB1, CPE-BP1, CPEB, CPEB-1, h-CPEB, hCPEB-1 |
| Background: | This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. |
| UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 15q25.2 Cellular Component: postsynaptic membrane; dendrite; postsynaptic density; cytoplasm; nucleus; cell junction Molecular Function:metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding Biological Process: synaptonemal complex assembly; cellular response to insulin stimulus; mRNA processing; regulation of neuronal synaptic plasticity |
| NCBI Summary: | This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q9BZB8 |
| NCBI GenInfo Identifier: | 74762720 |
| NCBI Gene ID: | 64506 |
| NCBI Accession: | Q9BZB8.1 |
| UniProt Secondary Accession: | Q9BZB8,P70166, P0C279, |
| UniProt Related Accession: | Q9BZB8 |
| Molecular Weight: | 53,635 Da |
| NCBI Full Name: | Cytoplasmic polyadenylation element-binding protein 1 |
| NCBI Synonym Full Names: | cytoplasmic polyadenylation element binding protein 1 |
| NCBI Official Symbol: | CPEB1 |
| NCBI Official Synonym Symbols: | CPEB; CPEB-1; CPE-BP1; hCPEB-1 |
| NCBI Protein Information: | cytoplasmic polyadenylation element-binding protein 1; CPE-binding protein 1 |
| UniProt Protein Name: | Cytoplasmic polyadenylation element-binding protein 1 |
| Protein Family: | C-phycoerythrin |
| UniProt Gene Name: | CPEB1 |
| UniProt Entry Name: | CPEB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPEB1 antibody (CAB5913) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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