Anti-CPA3 Antibody (CAB15658)

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SKU:
CAB15658
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CPA3 Antibody
Antibody SKU:CAB15658
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-417 of human CPA3 (NP_001861.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse pancreas, Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-417 of human CPA3 (NP_001861.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IPGR HSYA KYNN WEKI VAWT EKMM DKYP EMVS RIKI GSTV EDNP LYVL KIGE KNER RKAI FTDC GIHA REWV SPAF CQWF VYQA TKTY GRNK IMTK LLDR MNFY ILPV FNVD GYIW SWTK NRMW RKNR SKNQ NSKC IGTD LNRN FNAS WNSI PNTN DPCA DNYR GSAP ESEK ETKA VTNF IRSH LNEI KVYI TFHS YSQM LLFP YGYT SKLP PNHE DLAK VAKI GTDV LSTR YETR YIYG PIES TIYP ISGS SLDW AYDL GIKH TFAF ELRD KGKF GFLL PESR IKPT CRET MLAV KFIA KYIL KHTS
Gene ID:1359
Uniprot:P15088
Cellular Location:Cytoplasmic vesicle, secretory vesicle
Calculated MW:48kDa
Observed MW:55kDa
Synonyms:CPA3, MC-CPA
Background:This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients.
UniProt Protein Function:CPA3: Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase. [provided by RefSeq, Jan 2009]
UniProt Protein Details:

Protein type:EC 3.4.17.1; Protease

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: extracellular region; extracellular space

Molecular Function:metallocarboxypeptidase activity

Biological Process: angiotensin maturation; positive regulation of defense response to virus by host; proteolysis

NCBI Summary:This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
UniProt Code:P15088
NCBI GenInfo Identifier:317373331
NCBI Gene ID:1359
NCBI Accession:P15088.2
UniProt Secondary Accession:P15088,Q96E94,
UniProt Related Accession:P15088
Molecular Weight:48,670 Da
NCBI Full Name:Mast cell carboxypeptidase A
NCBI Synonym Full Names:carboxypeptidase A3
NCBI Official Symbol:CPA3  
NCBI Official Synonym Symbols:MC-CPA  
NCBI Protein Information:mast cell carboxypeptidase A
UniProt Protein Name:Mast cell carboxypeptidase A
UniProt Synonym Protein Names:Carboxypeptidase A3
Protein Family:Mast cell carboxypeptidase
UniProt Gene Name:CPA3  
UniProt Entry Name:CBPA3_HUMAN
Anti-CPA3 Antibody (CAB15658)Western blot analysis of extracts of various cell lines, using CPA3 antibody (CAB15658) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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