| Background: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. |
| UniProt Protein Function: | COX7A2L: May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen. Belongs to the cytochrome c oxidase VIIa family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Mitochondrial; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 2p21 Cellular Component: mitochondrial inner membrane Biological Process: mitochondrial electron transport, cytochrome c to oxygen |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | O14548 |
| NCBI GenInfo Identifier: | 20141187 |
| NCBI Gene ID: | 9167 |
| NCBI Accession: | O14548.2 |
| UniProt Secondary Accession: | O14548,Q9P118, |
| UniProt Related Accession: | O14548 |
| Molecular Weight: | 12,615 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit 7A2 like |
| NCBI Official Symbol: | COX7A2L |
| NCBI Official Synonym Symbols: | EB1; SIG81; COX7AR; COX7RP |
| NCBI Protein Information: | cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| UniProt Synonym Protein Names: | COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1 |
| Protein Family: | Cytochrome c oxidase subunit 7A-related protein |
| UniProt Gene Name: | COX7A2L |
| UniProt Entry Name: | COX7R_HUMAN |
