Anti-Cornulin Antibody (CAB8762)
- SKU:
- CAB8762
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-Cornulin Antibody |
Antibody SKU: | CAB8762 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:1000 |
Reactivity: | Human, Mouse |
Positive Samples: | HeLa, TE-1, 293T, HepG2, Mouse kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | GETV PGGQ AQTG ASTE SGRQ EWSS THPR RCVT EGQG DRQP TVVG EEWV DDHS RETV ILRL DQGN LHTS VSSA QGQD AAQS EEKR GITA RELY SYLR STKP |
Gene ID: | 49860 |
Uniprot: | Q9UBG3 |
Cellular Location: | Cytoplasm |
Calculated MW: | 53kDa |
Observed MW: | 60kDa |
Synonyms: | CRNN, C1orf10, DRC1, PDRC1, SEP53, cornulin |
Background: | This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. |
UniProt Protein Function: | CRNN: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. Belongs to the S100-fused protein family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; membrane Molecular Function:calcium ion binding Biological Process: cell-cell adhesion; response to heat |
NCBI Summary: | This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009] |
UniProt Code: | Q9UBG3 |
NCBI GenInfo Identifier: | 7706635 |
NCBI Gene ID: | 49860 |
NCBI Accession: | NP_057274.1 |
UniProt Secondary Accession: | Q9UBG3,Q8N613, B2RE60, |
UniProt Related Accession: | Q9UBG3 |
Molecular Weight: | 53,533 Da |
NCBI Full Name: | cornulin |
NCBI Synonym Full Names: | cornulin |
NCBI Official Symbol: | CRNN |
NCBI Official Synonym Symbols: | DRC1; PDRC1; SEP53; C1orf10 |
NCBI Protein Information: | cornulin |
UniProt Protein Name: | Cornulin |
UniProt Synonym Protein Names: | 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein |
Protein Family: | Cornulin |
UniProt Gene Name: | CRNN |
UniProt Entry Name: | CRNN_HUMAN |