Anti-COLEC11 Antibody (CAB4955)
- SKU:
- CAB4955
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- COLEC11
- 3MC2
- CL-K1-I
- CL-K1-II
- CL-K1-IIa
- CL-K1-IIb
- CLK1
Frequently bought together:
Description
| Product Name: | COLEC11 Rabbit pAb |
| Product Code: | CAB4955 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | COLEC11, 3MC2, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, CLK1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-271 of human COLEC11 (NP_076932.1). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:200 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | MCF7, THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-271 of human COLEC11 (NP_076932.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPAG DDAC SVQI LVPG LKGD AGEK GDKG APGR PGRV GPTG EKGD MGDK GQKG SVGR HGKI GPIG SKGE KGDS GDIG PPGP NGEP GLPC ECSQ LRKA IGEM DNQV SQLT SELK FIKN AVAG VRET ESKI YLLV KEEK RYAD AQLS CQGR GGTL SMPK DEAA NGLM AAYL AQAG LARV FIGI NDLE KEGA FVYS DHSP MRTF NKWR SGEP NNAY DEED CVEM VASG GWND VACH TTMY FMCE FDKE NM |
| Gene ID: | 78989 |
| Uniprot: | Q9BWP8 |
| Cellular Location: | Secreted |
| Calculated MW: | 21kDa/23kDa/24kDa/26kDa/28kDa/29kDa/30kDa |
| Observed MW: | 35kDa |
| UniProt Protein Function: | Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). |
| NCBI Summary: | This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9BWP8 |
| NCBI GenInfo Identifier: | 13128972 |
| NCBI Gene ID: | 78989 |
| NCBI Accession: | NP_076932 |
| UniProt Related Accession: | Q9BWP8 |
| Molecular Weight: | 28.665 |
| NCBI Full Name: | collectin-11 isoform a |
| NCBI Synonym Full Names: | collectin subfamily member 11 |
| NCBI Official Symbol: | COLEC11 |
| NCBI Official Synonym Symbols: | 3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb |
| NCBI Protein Information: | collectin-11 |
| UniProt Protein Name: | Collectin-11 |
| UniProt Synonym Protein Names: | Collectin kidney protein 1; CL-K1 |
| Protein Family: | Collectin |
| UniProt Gene Name: | COLEC11 |
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