Anti-COG4 Antibody (CAB16111)
- SKU:
- CAB16111
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-COG4 Antibody |
| Antibody SKU: | CAB16111 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-410 of human COG4 (NP_056201.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Mouse liver, Mouse lung, Rat pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-410 of human COG4 (NP_056201.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQVE CDRQ VEKV VDKF IKQR DYHQ QFRH VQNN LMRN STTE KIEP RELD PILT EVTL MNAR SELY LRFL KKRI SSDF EVGD SMAS EEVK QEHQ KCLD KLLN N |
| Gene ID: | 25839 |
| Uniprot: | Q9H9E3 |
| Cellular Location: | Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein |
| Calculated MW: | 38kDa/81kDa/89kDa |
| Observed MW: | 100kDa |
| Synonyms: | COG4, CDG2J, COD1 |
| Background: | The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | COG4: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J). It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG4 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: Golgi membrane; Golgi transport complex; trans-Golgi network membrane Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; Golgi vesicle prefusion complex stabilization; retrograde transport, vesicle recycling within Golgi; retrograde vesicle-mediated transport, Golgi to ER Disease: Congenital Disorder Of Glycosylation, Type Iij |
| NCBI Summary: | The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] |
| UniProt Code: | Q9H9E3 |
| NCBI GenInfo Identifier: | 311033464 |
| NCBI Gene ID: | 25839 |
| NCBI Accession: | Q9H9E3.3 |
| UniProt Secondary Accession: | Q9H9E3,Q96D40, Q9BRF0, Q9BVZ2, Q9H5Y4, Q9Y3W3, B4DMN8 C9JS23, |
| UniProt Related Accession: | Q9H9E3 |
| Molecular Weight: | 81,098 Da |
| NCBI Full Name: | Conserved oligomeric Golgi complex subunit 4 |
| NCBI Synonym Full Names: | component of oligomeric golgi complex 4 |
| NCBI Official Symbol: | COG4 |
| NCBI Official Synonym Symbols: | COD1; CDG2J |
| NCBI Protein Information: | conserved oligomeric Golgi complex subunit 4 |
| UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 4 |
| UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 4 |
| Protein Family: | Conserved oligomeric Golgi complex |
| UniProt Gene Name: | COG4 |
| UniProt Entry Name: | COG4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COG4 antibody (CAB16111) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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