Anti-COG2 Antibody (CAB6251)
- SKU:
- CAB6251
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-COG2 Antibody |
| Antibody SKU: | CAB6251 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human COG2 (NP_031383.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, HepG2, MCF7, Mouse kidney, Rat testis, Rat stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human COG2 (NP_031383.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEKS RMNL PKGP DTLC FDKD EFMK EDFD VDHF VSDC RKRV QLEE LRDD LELY YKLL KTAM VELI NKDY ADFV NLST NLVG MDKA LNQL SVPL GQLR EEVL SLRS SVSE GIRA VDER MSKQ EDIR KKKM CVLR LIQV IRSV EKIE KILN SQSS KETS ALEA SSPL LTGQ ILER IATE FNQL QFHA VQSK GMPL LDKV RPRI AGIT AMLQ QSLE GLLL EGLQ TSDV DIIR HCLR TYAT IDKT RDAE ALVG QVLV KPYI DEVI IEQF VESH PNGL QVMY NKLL |
| Gene ID: | 22796 |
| Uniprot: | Q14746 |
| Cellular Location: | Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein |
| Calculated MW: | 83kDa |
| Observed MW: | 88kDa |
| Synonyms: | COG2, LDLC, CDG2Q |
| Background: | This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | COG2: Required for normal Golgi morphology and function. Belongs to the COG2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: Golgi membrane; Golgi stack; Golgi transport complex; cytosol Molecular Function:protein binding; protein complex binding; protein transporter activity Biological Process: intracellular protein transport; intra-Golgi vesicle-mediated transport; oligosaccharide biosynthetic process; protein amino acid glycosylation; Golgi organization and biogenesis |
| NCBI Summary: | This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] |
| UniProt Code: | Q14746 |
| NCBI GenInfo Identifier: | 2498512 |
| NCBI Gene ID: | 22796 |
| NCBI Accession: | Q14746.1 |
| UniProt Secondary Accession: | Q14746,Q86U99, |
| UniProt Related Accession: | Q14746 |
| Molecular Weight: | 738 |
| NCBI Full Name: | Conserved oligomeric Golgi complex subunit 2 |
| NCBI Synonym Full Names: | component of oligomeric golgi complex 2 |
| NCBI Official Symbol: | COG2 |
| NCBI Official Synonym Symbols: | LDLC |
| NCBI Protein Information: | conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; conserved oligomeric Golgi complex protein 2; brefeldin A-sensitive, peripheral Golgi protein; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein |
| UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 2 |
| UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein |
| Protein Family: | Conserved oligomeric Golgi complex |
| UniProt Gene Name: | COG2 |
| UniProt Entry Name: | COG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COG2 antibody (CAB6251) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 80s. |
 | Immunohistochemistry of paraffin-embedded rat brain using COG2 antibody (CAB6251) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using COG2 antibody (CAB6251) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using COG2 Polyclonal Antibody (CAB6251) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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