Anti-Cofilin-2 Antibody (CAB8009)

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SKU:
CAB8009
Product type:
Antibody
Application:
WB
Application:
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:CFL2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8009
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HeLa, Raji, NCI-H460, Mouse heart, Mouse skeletal muscle, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASG VTVN DEVI KVFN DMKV RKSS TQEE IKKR KKAV LFCL SDDK RQII VEEA KQIL VGDI GDTV EDPY TSFV KLLP LNDC RYAL YDAT YETK ESKK EDLV FIFW APES APLK SKMI YASS KDAI KKKF TGIK HEWQ VNGL DDIK DRST LGEK LGGN VVVS LEGK PL
Gene ID:1073
Uniprot:Q9Y281
Cellular Location:Cytoplasm, Nucleus matrix, cytoskeleton
Calculated MW:16kDa/18kDa
Observed MW:18kDa
Synonyms:CFL2, NEM7, cofilin-2
Background:This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: extracellular space; I band

Molecular Function:protein binding

Biological Process: positive regulation of actin filament depolymerization

Disease: Nemaline Myopathy 7

NCBI Summary:This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
UniProt Code:Q9Y281
NCBI GenInfo Identifier:6831517
NCBI Gene ID:1073
NCBI Accession:Q9Y281.1
UniProt Secondary Accession:Q9Y281,G3V5P4,
UniProt Related Accession:Q9Y281
Molecular Weight:– Da
NCBI Full Name:Cofilin-2
NCBI Synonym Full Names:cofilin 2
NCBI Official Symbol:CFL2  
NCBI Official Synonym Symbols:NEM7  
NCBI Protein Information:cofilin-2
UniProt Protein Name:Cofilin-2
UniProt Synonym Protein Names:Cofilin, muscle isoform
Protein Family:Cofilin
UniProt Gene Name:CFL2  
UniProt Entry Name:COF2_HUMAN

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