Anti-CNTN6 Antibody (CAB14275)
- SKU:
- CAB14275
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CNTN6 Antibody |
| Antibody SKU: | CAB14275 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human CNTN6 (NP_055276.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human CNTN6 (NP_055276.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DGLL SRPI FTQE PHDV IFPL DLSK SEVI LNCA ANGY PSPH YRWK QNGT DIDF TMSY HYRL DGGS LAIN SPHT DQDI GMYQ CLAT NLLG TIL |
| Gene ID: | 27255 |
| Uniprot: | Q9UQ52 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 113kDa |
| Observed MW: | 114kDa |
| Synonyms: | CNTN6, NB3 |
| Background: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CNTN6: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Belongs to the immunoglobulin superfamily. Contactin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Cell adhesion Chromosomal Location of Human Ortholog: 3p26.3 Cellular Component: plasma membrane Biological Process: axon guidance; Notch signaling pathway; central nervous system development; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQ52 |
| NCBI GenInfo Identifier: | 7657361 |
| NCBI Gene ID: | 27255 |
| NCBI Accession: | NP_055276.1 |
| UniProt Secondary Accession: | Q9UQ52,Q2KHM2, |
| UniProt Related Accession: | Q9UQ52 |
| Molecular Weight: | 113,956 Da |
| NCBI Full Name: | contactin-6 |
| NCBI Synonym Full Names: | contactin 6 |
| NCBI Official Symbol: | CNTN6 |
| NCBI Official Synonym Symbols: | NB3 |
| NCBI Protein Information: | contactin-6; neural adhesion molecule; neural recognition molecule NB-3 |
| UniProt Protein Name: | Contactin-6 |
| UniProt Synonym Protein Names: | Neural recognition molecule NB-3 |
| Protein Family: | Contactin |
| UniProt Gene Name: | CNTN6 |
| UniProt Entry Name: | CNTN6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNTN6 antibody (CAB14275) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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