Anti-CNTF Antibody (CAB1915)
- SKU:
- CAB1915
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CNTF Antibody |
| Antibody SKU: | CAB1915 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CNTF (NP_000605.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CNTF (NP_000605.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAFT EHSP LTPH RRDL CSRS IWLA RKIR SDLT ALTE SYVK HQGL NKNI NLDS ADGM PVAS TDQW SELT EAER LQEN LQAY RTFH VLLA RLLE DQQV HFTP TEGD FHQA IHTL LLQV AAFA YQIE ELMI LLEY KIPR NEAD GMPI NVGD GGLF EKKL WGLK VLQE LSQW TVRS IHDL RFIS SHQT GIPA RGSH YIAN NKKM |
| Gene ID: | 1270 |
| Uniprot: | P26441 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa |
| Observed MW: | 26kDa |
| Synonyms: | CNTF, HCNTF |
| Background: | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. |
| UniProt Protein Function: | CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q12.2 Cellular Component: cytoplasm; extracellular region; extracellular space Molecular Function:ciliary neurotrophic factor receptor binding; growth factor activity; interleukin-6 receptor binding; protein binding Biological Process: growth; muscle morphogenesis; negative regulation of neuron apoptosis; negative regulation of photoreceptor cell differentiation; neuron development; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of retinal cell programmed cell death; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010] |
| UniProt Code: | P26441 |
| NCBI GenInfo Identifier: | 116585 |
| NCBI Gene ID: | 1270 |
| NCBI Accession: | P26441.1 |
| UniProt Secondary Accession: | P26441,B2RAB2, |
| UniProt Related Accession: | P26441 |
| Molecular Weight: | |
| NCBI Full Name: | Ciliary neurotrophic factor |
| NCBI Synonym Full Names: | ciliary neurotrophic factor |
| NCBI Official Symbol: | CNTF |
| NCBI Official Synonym Symbols: | HCNTF |
| NCBI Protein Information: | ciliary neurotrophic factor |
| UniProt Protein Name: | Ciliary neurotrophic factor |
| Protein Family: | Ciliary neurotrophic factor |
| UniProt Gene Name: | CNTF |
| UniProt Entry Name: | CNTF_HUMAN |
 | Western blot analysis of extracts of mouse muscle, using CNTF antibody (CAB1915) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of C6 cells using CNTF Rabbit pAb (CAB1915) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse spinal cord using CNTF Rabbit pAb (CAB1915) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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