Anti-CMPK1 Antibody (CAB6561)

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SKU:
CAB6561
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-CMPK1 Antibody
Antibody SKU:CAB6561
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 69-228 of human CMPK1 (NP_057392.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T, HL-60, HT-29, HeLa, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 69-228 of human CMPK1 (NP_057392.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLRD ERKN PDSQ YGEL IEKY IKEG KIVP VEIT ISLL KREM DQTM AANA QKNK FLID GFPR NQDN LQGW NKTM DGKA DVSF VLFF DCNN EICI ERCL ERGK SSGR SDDN RESL EKRI QTYL QSTK PIID LYEE MGKV KKID ASKS VDEV FDEV VQIF DKEG
Gene ID:51727
Uniprot:P30085
Cellular Location:Cytoplasm, Nucleus
Calculated MW:16kDa/22kDa
Observed MW:22kDa
Synonyms:CMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK
Background:This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants.
UniProt Protein Function:CMPK: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP. Belongs to the adenylate kinase family.
UniProt Protein Details:

Protein type:EC 2.7.4.14; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Kinase, other

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:ATP binding; cytidylate kinase activity; nucleoside diphosphate kinase activity; uridine kinase activity; uridylate kinase activity

Biological Process: 'de novo' pyrimidine base biosynthetic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process; UMP biosynthetic process

NCBI Summary:This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
UniProt Code:P30085
NCBI GenInfo Identifier:12644008
NCBI Gene ID:51727
NCBI Accession:P30085.3
UniProt Secondary Accession:P30085,Q53GB7, Q5SVZ0, Q96C07, Q9UBQ8, Q9UIA2, B4DPU7 E9PGI8,
UniProt Related Accession:P30085
Molecular Weight:16,548 Da
NCBI Full Name:UMP-CMP kinase
NCBI Synonym Full Names:cytidine/uridine monophosphate kinase 1
NCBI Official Symbol:CMPK1  
NCBI Official Synonym Symbols:CK; CMK; UMK; CMPK; UMPK; UMP-CMPK  
NCBI Protein Information:UMP-CMP kinase
UniProt Protein Name:UMP-CMP kinase
UniProt Synonym Protein Names:Deoxycytidylate kinase
UniProt Gene Name:CMPK1  
UniProt Entry Name:KCY_HUMAN
Anti-CMPK1 Antibody (CAB6561)Western blot analysis of extracts of various cell lines, using CMPK1 antibody (CAB6561) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CMPK1 Antibody (CAB6561)Immunofluorescence analysis of MCF7 cells using CMPK1 antibody (CAB6561). Blue: DAPI for nuclear staining.

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