Anti-CLTA Antibody (CAB3793)
- SKU:
- CAB3793
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-CLTA Antibody |
| Antibody SKU: | CAB3793 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human CLTA (NP_001824.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, NCI-H460, HeLa, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human CLTA (NP_001824.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEL DPFG APAG APGG PALG NGVA GAGE EDPA AAFL AQQE SEIA GIEN DEAF AILD GGAP GPQP HGEP PGGP DAVD GVMN GEYY QESN GPTD SYAA ISQV DRLQ SEPE SIRK WREE QMER LEAL DANS RKQE AEWK EKAI KELE EWYA RQDE QLQK TKAN NRAA EEAF VNDI DESS PGTE WERV ARLC DFNP KSSK QAKD VSRM RSVL ISLK QAPL VH |
| Gene ID: | 1211 |
| Uniprot: | P09496 |
| Cellular Location: | Cytoplasmic side, Cytoplasmic vesicle membrane, Membrane, Peripheral membrane protein, coated pit |
| Calculated MW: | 17kDa/23kDa/24kDa/25kDa/27kDa |
| Observed MW: | 33kDa |
| Synonyms: | CLTA, LCA |
| Background: | Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. |
| UniProt Protein Function: | CLTA: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Belongs to the clathrin light chain family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 9p13 Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; intracellular membrane-bound organelle; membrane; cytoplasmic membrane-bound vesicle; plasma membrane; trans-Golgi network membrane; cytosol; clathrin coat of coated pit Molecular Function:protein binding; clathrin heavy chain binding; structural molecule activity; peptide binding Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; axon guidance; intracellular protein transport; nerve growth factor receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; post-Golgi vesicle-mediated transport |
| NCBI Summary: | Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010] |
| UniProt Code: | P09496 |
| NCBI GenInfo Identifier: | 116501 |
| NCBI Gene ID: | 1211 |
| NCBI Accession: | P09496.1 |
| UniProt Related Accession: | P09496 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | Clathrin light chain A |
| NCBI Synonym Full Names: | clathrin light chain A |
| NCBI Official Symbol: | CLTA |
| NCBI Official Synonym Symbols: | LCA |
| NCBI Protein Information: | clathrin light chain A |
| UniProt Protein Name: | Clathrin light chain A |
| Protein Family: | Clathrin |
| UniProt Gene Name: | CLTA |
| UniProt Entry Name: | CLCA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLTA antibody (CAB3793) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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