Anti-CLIC3 Antibody (CAB15347)

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SKU:
CAB15347
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
Frequently bought together:

Description

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Antibody Name:Anti-CLIC3 Antibody
Antibody SKU:CAB15347
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GPPD FPSL APRY RESN TAGN DVFH KFSA FIKN PVPA QDEA LYQQ LLRA LARL DSYL RAPL EHEL AGEP QLRE SRRR FLDG DRLT LADC SLLP KLHI VDTV CAHF RQAP IPAE LRGV RRYL DSAM QEKE FKYT CPHS AEIL AAYR PAVH PR
Gene ID:9022
Uniprot:O95833
Cellular Location:Cytoplasm, Membrane, Nucleus, Single-pass membrane protein
Calculated MW:26kDa
Observed MW:27kDa
Synonyms:CLIC3
Background:Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family.
UniProt Protein Function:CLIC3: Can insert into membranes and form chloride ion channels. May participate in cellular growth control. Belongs to the chloride channel CLIC family.
UniProt Protein Details:

Protein type:Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; nucleus

Molecular Function:chloride channel activity; glutathione transferase activity; protein binding; voltage-gated ion channel activity

Biological Process: chloride transport; glutathione metabolic process; signal transduction

NCBI Summary:Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
UniProt Code:O95833
NCBI GenInfo Identifier:46397812
NCBI Gene ID:9022
NCBI Accession:O95833.2
UniProt Secondary Accession:O95833,Q5SPZ7,
UniProt Related Accession:O95833
Molecular Weight:26,648 Da
NCBI Full Name:Chloride intracellular channel protein 3
NCBI Synonym Full Names:chloride intracellular channel 3
NCBI Official Symbol:CLIC3  
NCBI Protein Information:chloride intracellular channel protein 3
UniProt Protein Name:Chloride intracellular channel protein 3
Protein Family:Chloride intracellular channel protein
UniProt Gene Name:CLIC3  
UniProt Entry Name:CLIC3_HUMAN
Anti-CLIC3 Antibody (CAB15347)Western blot analysis of extracts of various cell lines, using CLIC3 antibody (CAB15347) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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