Anti-Claudin-18 Antibody (CAB8392)

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SKU:
CAB8392
Product type:
Antibody
Application:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-Claudin-18 Antibody
Antibody SKU:CAB8392
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN18 (NP_057453.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, 293T, B cells, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN18 (NP_057453.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GCIA ATGM DMWS TQDL YDNP VTSV FQYE GLWR SCVR QSSG FTEC RPYF TILG LPAM LQAV R
Gene ID:51208
Uniprot:P56856
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:27kDa
Observed MW:28kDa
Synonyms:CLDN18, SFTA5, SFTPJ
Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
NCBI Summary:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
UniProt Code:P56856
NCBI GenInfo Identifier:7387578
NCBI Gene ID:51208
NCBI Accession:P56856.1
UniProt Secondary Accession:P56856,Q96PH4, A5PL21,
UniProt Related Accession:P56856
Molecular Weight:27,720 Da
NCBI Full Name:Claudin-18
NCBI Synonym Full Names:claudin 18
NCBI Official Symbol:CLDN18  
NCBI Official Synonym Symbols:SFTA5; SFTPJ  
NCBI Protein Information:claudin-18
UniProt Protein Name:Claudin-18
Protein Family:Claudin
UniProt Gene Name:CLDN18  
UniProt Entry Name:CLD18_HUMAN
Anti-Claudin-18 Polyclonal Antibody (CAB8392)Western blot analysis of extracts of various cell lines, using CLDN18 antibody (CAB8392) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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