Anti-CIRBP Antibody (CAB6080)
- SKU:
- CAB6080
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CIRBP Antibody |
| Antibody SKU: | CAB6080 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CIRBP (NP_001271.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CIRBP (NP_001271.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASD EGKL FVGG LSFD TNEQ SLEQ VFSK YGQI SEVV VVKD RETQ RSRG FGFV TFEN IDDA KDAM MAMN GKSV DGRQ IRVD QAGK SSDN RSRG YRGG SAGG RGFF RGGR GRGR GFSR GGGD RGYG GNRF ESRS GGYG GSRD YYSS RSQS GGYS DRSS GGSY RDSY DSYA THNE |
| Gene ID: | 1153 |
| Uniprot: | Q14011 |
| Cellular Location: | Cytoplasm, Nucleus, nucleoplasm |
| Calculated MW: | 18kDa/26kDa/28kDa |
| Observed MW: | 18KDa |
| Synonyms: | CIRBP, CIRP |
| Background: |
| UniProt Protein Function: | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. |
| UniProt Code: | Q14011 |
| NCBI GenInfo Identifier: | 5921786 |
| NCBI Gene ID: | 1153 |
| NCBI Accession: | Q14011.1 |
| UniProt Secondary Accession: | Q14011,B3KT17, B4E2X2, |
| UniProt Related Accession: | Q14011 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | Cold-inducible RNA-binding protein |
| NCBI Synonym Full Names: | cold inducible RNA binding protein |
| NCBI Official Symbol: | CIRBP |
| NCBI Official Synonym Symbols: | CIRP |
| NCBI Protein Information: | cold-inducible RNA-binding protein |
| UniProt Protein Name: | Cold-inducible RNA-binding protein |
| UniProt Synonym Protein Names: | A18 hnRNP; Glycine-rich RNA-binding protein CIRP |
| Protein Family: | Cold-inducible RNA-binding protein |
| UniProt Gene Name: | CIRBP |
 | Western blot analysis of extracts of Rat testis, using CIRBP Rabbit pAb (CAB6080) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using CIRBP antibody (CAB6080) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using CIRBP antibody (CAB6080) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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