Anti-CIC Antibody (CAB15408)
- SKU:
- CAB15408
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-CIC Antibody |
| Antibody SKU: | CAB15408 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LATS PRAI LGSY RKKR KNST DLDS APED PTSP KRKM RRRS SCSS EPNT PKSA KCEG DIFT FDRT GTEA EDVL GELE YDKV PYSS LRRT LDQR RALV MQLF QDHG FFPS AQAT AAFQ ARYA DIFP SKVC LQLK IREV RQKI MQAA TPTE QPPG AEAP LPVP PPTG TAAA PAPT PSPA GGPD PTSP SSDS GTAQ AAPP LPPP PESG PGQP GWEG APQP SPPP PGPS TAAT GR |
| Gene ID: | 23152 |
| Uniprot: | Q96RK0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 163kDa |
| Observed MW: | 164kDa |
| Synonyms: | CIC |
| Background: | The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | capicua: involved in cerebellar development and ErbB signaling. Significantly expressed in medulloblastomas. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: nucleus Molecular Function:protein binding Biological Process: negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q96RK0 |
| NCBI GenInfo Identifier: | 116241300 |
| NCBI Gene ID: | 23152 |
| NCBI Accession: | Q96RK0.2 |
| UniProt Secondary Accession: | Q96RK0,Q7LGI1, Q9UEG5, Q9Y6T1, |
| UniProt Related Accession: | Q96RK0 |
| Molecular Weight: | 163,820 Da |
| NCBI Full Name: | Protein capicua homolog |
| NCBI Synonym Full Names: | capicua transcriptional repressor |
| NCBI Official Symbol: | CIC |
| NCBI Protein Information: | protein capicua homolog |
| UniProt Protein Name: | Protein capicua homolog |
| Protein Family: | Cicadin |
| UniProt Gene Name: | CIC |
| UniProt Entry Name: | CIC_HUMAN |
 | Western blot analysis of extracts of NIH/3T3, using CIC antibody (CAB15408) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-WBP1 Antibody (CAB13212)
