| UniProt Protein Function: | CTF18: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; membrane; nucleoplasm Molecular Function:DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity |
| NCBI Summary: | This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q8WVB6 |
| NCBI GenInfo Identifier: | 74751544 |
| NCBI Gene ID: | 63922 |
| NCBI Accession: | Q8WVB6.1 |
| UniProt Secondary Accession: | Q8WVB6,Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3, B7ZBA2 D3DU68, |
| UniProt Related Accession: | Q8WVB6 |
| Molecular Weight: | 61,869 Da |
| NCBI Full Name: | Chromosome transmission fidelity protein 18 homolog |
| NCBI Synonym Full Names: | chromosome transmission fidelity factor 18 |
| NCBI Official Symbol: | CHTF18 |
| NCBI Official Synonym Symbols: | CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4 |
| NCBI Protein Information: | chromosome transmission fidelity protein 18 homolog |
| UniProt Protein Name: | Chromosome transmission fidelity protein 18 homolog |
| UniProt Synonym Protein Names: | CHL12 |
| Protein Family: | Chromosome transmission fidelity protein |
| UniProt Gene Name: | CHTF18 |
| UniProt Entry Name: | CTF18_HUMAN |
