Anti-Chromogranin A Antibody (CAB9576)

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SKU:
CAB9576
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CGA
Frequently bought together:

Description

Product Name:Chromogranin A Rabbit mAb
Product Code:CAB9576
Size:20uL, 50uL, 100uL
Synonyms:CGA
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Chromogranin A
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:PC-12, SH-SY5Y
Immunogen:A synthesized peptide derived from human Chromogranin A
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1113
Uniprot:P10645
Calculated MW:90kDa
Observed MW:80KDa
UniProt Protein Function:CHGA: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Vesicle; Cell adhesion

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: extracellular space; perinuclear region of cytoplasm; secretory granule

Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; mast cell activation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; negative regulation of catecholamine secretion; negative regulation of vasodilation; organelle organization and biogenesis; positive regulation of cAMP metabolic process; regulation of blood pressure; regulation of the force of heart contraction

NCBI Summary:The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Code:P10645
NCBI GenInfo Identifier:215274270
NCBI Gene ID:1113
NCBI Accession:P10645.7
UniProt Secondary Accession:P10645,Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5, B2R9E9
UniProt Related Accession:P10645
Molecular Weight:50,688 Da
NCBI Full Name:Chromogranin-A
NCBI Synonym Full Names:chromogranin A
NCBI Official Symbol:CHGA  
NCBI Official Synonym Symbols:CGA  
NCBI Protein Information:chromogranin-A
UniProt Protein Name:Chromogranin-A
UniProt Synonym Protein Names:SL21
Protein Family:Chromogranin
UniProt Gene Name:CHGA  
UniProt Entry Name:CMGA_HUMAN

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