Anti-CHRNA10 Antibody (CAB3042)
- SKU:
- CAB3042
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CHRNA10 Antibody |
| Antibody SKU: | CAB3042 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | HL-60, U2OS |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AEGR LALK LFRD LFAN YTSA LRPV ADTD QTLN VTLE VTLS QIID MDER NQVL TLYL WIRQ EWTD AYLR WDPN AYGG LDAI RIPS SLVW RPDI VLYN KADA QPPG SAST NVVL RHDG AVRW DAPA ITRS SCRV DVAA FPFD AQHC GLTF GSWT HGGH QLDV RPRG AAAS LADF VENV EWRV LGMP ARRR VLTY GCCS EPYP DVTF TLLL RRRA AAYV |
| Gene ID: | 57053 |
| Uniprot: | Q9GZZ6 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 49kDa |
| Observed MW: | 45kDa |
| Synonyms: | CHRNA10 |
| Background: |
| UniProt Protein Function: | nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily. |
| UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex Molecular Function:acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic |
| UniProt Code: | Q9GZZ6 |
| NCBI GenInfo Identifier: | 14916526 |
| NCBI Gene ID: | 57053 |
| NCBI Accession: | Q9GZZ6.1 |
| UniProt Related Accession: | Q9GZZ6 |
| Molecular Weight: | 49,705 Da |
| NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-10 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 10 subunit |
| NCBI Official Symbol: | CHRNA10 |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-10 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-10 |
| UniProt Synonym Protein Names: | Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10 |
| Protein Family: | Neuronal acetylcholine receptor |
| UniProt Gene Name: | CHRNA10 |
| UniProt Entry Name: | ACH10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHRNA10 antibody (CAB3042) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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