| UniProt Protein Function: | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. |
| NCBI Summary: | CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q7LBR1 |
| NCBI GenInfo Identifier: | 31542306 |
| NCBI Gene ID: | 57132 |
| NCBI Accession: | NP_065145 |
| UniProt Secondary Accession: | Q7LBR1,Q96E89, Q9HD41, |
| UniProt Related Accession: | Q7LBR1 |
| Molecular Weight: | 24.7 kDa (223aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher) |
| NCBI Full Name: | charged multivesicular body protein 1b |
| NCBI Synonym Full Names: | charged multivesicular body protein 1B |
| NCBI Official Symbol: | CHMP1B |
| NCBI Official Synonym Symbols: | Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2 |
| NCBI Protein Information: | charged multivesicular body protein 1b |
| UniProt Protein Name: | Charged multivesicular body protein 1b |
| UniProt Synonym Protein Names: | CHMP1.5; Chromatin-modifying protein 1b; CHMP1b; Vacuolar protein sorting-associated protein 46-2; Vps46-2; hVps46-2 |
| Protein Family: | Charged multivesicular body protein |
| UniProt Gene Name: | CHMP1B |
