Anti-CETP Antibody (CAB1355)
- SKU:
- CAB1355
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CETP Antibody |
| Antibody SKU: | CAB1355 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-493 of human CETP (NP_000069.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HepG2, A375, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-493 of human CETP (NP_000069.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LMLS LMGD EFKA VLET WGFN TNQE IFQE VVGG FPSQ AQVT VHCL KMPK ISCQ NKGV VVNS SVMV KFLF PRPD QQHS VAYT FEED IVTT VQAS YSKK KLFL SLLD FQIT PKTV SNLT ESSS ESVQ SFLQ SMIT AVGI PEVM SRLE VVFT ALMN SKGV SLFD IINP EIIT RDGF LLLQ MDFG FPEH LLVD FLQS LS |
| Gene ID: | 1071 |
| Uniprot: | P11597 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 47kDa/54kDa |
| Observed MW: | 75kDa |
| Synonyms: | CETP, BPIFF, HDLCQ10 |
| Background: | The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding; Secreted; Secreted, signal peptide; Vesicle Chromosomal Location of Human Ortholog: 16q21 Cellular Component: extracellular space; extracellular region; vesicle Molecular Function:lipid transporter activity; phospholipid transporter activity; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding; triglyceride binding Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; cholesterol transport; lipid homeostasis; lipoprotein metabolic process; lipid transport; phosphatidylcholine metabolic process; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; phospholipid transport; triacylglycerol transport; transmembrane transport; phospholipid homeostasis Disease: Hyperalphalipoproteinemia 1 |
| NCBI Summary: | The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] |
| UniProt Code: | P11597 |
| NCBI GenInfo Identifier: | 71153497 |
| NCBI Gene ID: | 1071 |
| NCBI Accession: | P11597.2 |
| UniProt Secondary Accession: | P11597,Q13987, Q13988, Q53YZ1, |
| UniProt Related Accession: | P11597 |
| Molecular Weight: | 47,787 Da |
| NCBI Full Name: | Cholesteryl ester transfer protein |
| NCBI Synonym Full Names: | cholesteryl ester transfer protein, plasma |
| NCBI Official Symbol: | CETP |
| NCBI Official Synonym Symbols: | BPIFF; HDLCQ10 |
| NCBI Protein Information: | cholesteryl ester transfer protein; lipid transfer protein I; BPI fold containing family F |
| UniProt Protein Name: | Cholesteryl ester transfer protein |
| UniProt Synonym Protein Names: | Lipid transfer protein I |
| Protein Family: | Cholesteryl ester transfer protein |
| UniProt Gene Name: | CETP |
| UniProt Entry Name: | CETP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CETP antibody (CAB1355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded mouse liver using CETP antibody (CAB1355) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using CETP antibody (CAB1355) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CETP antibody (CAB1355) (40x lens). |