Anti-CES3 Antibody (CAB4558)
- SKU:
- CAB4558
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CES3
- ES31
Frequently bought together:
Description
| Product Name: | CES3 Rabbit pAb |
| Product Code: | CAB4558 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CES3, ES31 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HT-29, Mouse small intestine, Mouse large intestine, Rat liver, Rat small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WPLA QKIA NTLA CSSS SPAE MVQC LQQK EGEE LVLS KKLK NTIY PLTV DGTV FPKS PKEL LKEK PFHS VPFL MGVN NHEF SWLI PRGW GLLD TMEQ MSRE DMLA ISTP VLTS LDVP PEMM PTVI DEYL GSNS DAQA KCQA FQEF MGDV FINV PTVS FSRY LRDS GSPV FFYE FQHR PSSF AKIK PAWV KADH GAEG AFVF GGPF LMDE SSRL EATE EEKQ LSLT MMAQ WTHF ARTG DPNS KALP PWPQ FNQA EQYL EINP VPRA GQKF REAW MQFW SETL PSKI QQWH QKQK NRKA QEDL |
| Gene ID: | 23491 |
| Uniprot: | Q6UWW8 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 24kDa/62kDa |
| Observed MW: | 62kDa |
| UniProt Protein Function: | CES3: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. Belongs to the type-B carboxylesterase/lipase family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Secreted, signal peptide; Secreted; Hydrolase; EC 3.1.1.1 Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: extracellular space; endoplasmic reticulum lumen Biological Process: metabolic process |
| NCBI Summary: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q6UWW8 |
| NCBI GenInfo Identifier: | 74758561 |
| NCBI Gene ID: | 23491 |
| NCBI Accession: | Q6UWW8.1 |
| UniProt Secondary Accession: | Q6UWW8,Q7Z6J1, Q9H6X7, B2Z3W9, F5H242, |
| UniProt Related Accession: | Q6UWW8 |
| Molecular Weight: | 24,106 Da |
| NCBI Full Name: | Carboxylesterase 3 |
| NCBI Synonym Full Names: | carboxylesterase 3 |
| NCBI Official Symbol: | CES3 |
| NCBI Official Synonym Symbols: | ES31 |
| NCBI Protein Information: | carboxylesterase 3; esterase 31; carboxylesterase 3 (brain); liver carboxylesterase 31 homolog |
| UniProt Protein Name: | Carboxylesterase 3 |
| UniProt Synonym Protein Names: | Liver carboxylesterase 31 homolog |
| Protein Family: | Carboxylesterase |
| UniProt Gene Name: | CES3 |
| UniProt Entry Name: | EST3_HUMAN |
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