Anti-CES1 Antibody (CAB11478)
- SKU:
- CAB11478
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CES1 Antibody |
| Antibody SKU: | CAB11478 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CES1 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse liver, Mouse kidney, Rat lung, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human CES1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1066 |
| Uniprot: | P23141 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 55kDa |
| Observed MW: | 63KDa |
 | Western blot - CES1 Rabbit mAb (CAB11478) |
| Synonyms: | ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 |
| Background: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Protein Function: | CES1: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.1.1.56; EC 3.1.1.1 Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: extracellular space; endoplasmic reticulum lumen Molecular Function:methylumbelliferyl-acetate deacetylase activity Biological Process: epithelial cell differentiation; metabolic process; response to toxin |
| NCBI Summary: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P23141 |
| NCBI GenInfo Identifier: | 119576 |
| NCBI Gene ID: | 1066 |
| NCBI Accession: | P23141.2 |
| UniProt Related Accession: | P23141 |
| Molecular Weight: | Predicted Molecular Mass: 34.0kDaAccurate Molecular Mass: 35kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | Liver carboxylesterase 1 |
| NCBI Synonym Full Names: | carboxylesterase 1 |
| NCBI Official Symbol: | CES1 |
| NCBI Official Synonym Symbols: | CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1 |
| NCBI Protein Information: | liver carboxylesterase 1 |
| UniProt Protein Name: | Liver carboxylesterase 1 |
| UniProt Synonym Protein Names: | Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1 (EC:3.1.1.1); CE-1; hCE-1; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1 (EC:3.1.1.56); Monocyte/macrophage serine esterase; Retinyl ester hydrolase; REH; Serine esterase 1; Triacylglycerol hydrolase; TGH |
| Protein Family: | Liver carboxylesterase |
| UniProt Gene Name: | CES1 |
| UniProt Entry Name: | EST1_HUMAN |
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