Anti-CERS5 Antibody (CAB17240)
- SKU:
- CAB17240
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CERS5 Antibody |
| Antibody SKU: | CAB17240 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CERS5 (NP_001268660.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CERS5 (NP_001268660.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMKP RPKR FIAK PCAL CIGI EDSG PYQA QPNA ILEK VFIS ITKY PDKK RLEG LSKQ LDWN VRKI QCWF RHRR NQDK PPTL TKFC ESMW RFTF YLCI FCYG |
| Gene ID: | 91012 |
| Uniprot: | Q8N5B7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CERS5, LASS5, Trh4 |
| Background: | This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | LASS5: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transferase; EC 2.3.1.24; DNA-binding Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane Molecular Function:DNA binding; sphingosine N-acyltransferase activity Biological Process: ceramide biosynthetic process; sphingolipid biosynthetic process |
| NCBI Summary: | This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q8N5B7 |
| NCBI GenInfo Identifier: | 22218345 |
| NCBI Gene ID: | 91012 |
| NCBI Accession: | NP_671723.1 |
| UniProt Secondary Accession: | Q8N5B7,B4DV54, |
| UniProt Related Accession: | Q8N5B7 |
| Molecular Weight: | 39,259 Da |
| NCBI Full Name: | ceramide synthase 5 isoform 1 |
| NCBI Synonym Full Names: | ceramide synthase 5 |
| NCBI Official Symbol: | CERS5 |
| NCBI Official Synonym Symbols: | Trh4; LASS5 |
| NCBI Protein Information: | ceramide synthase 5 |
| UniProt Protein Name: | Ceramide synthase 5 |
| UniProt Synonym Protein Names: | LAG1 longevity assurance homolog 5 |
| UniProt Gene Name: | CERS5 |
| UniProt Entry Name: | CERS5_HUMAN |
 | Western blot analysis of extracts of MCF7 cells, using CERS5 antibody (CAB17240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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