Anti-CEP112 Antibody (CAB14302)

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SKU:
CAB14302
Product type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CEP112 Antibody
Antibody SKU:CAB14302
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CEP112 (NP_659473.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HeLa, A-549, NCI-H460, 293T, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CEP112 (NP_659473.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEVG SEEE KWEK LDAE FDHF VVDM KPFV LKLP HRTE RQRC ALWI RKLC EPSG TGAG IMGR KNRN LYAK LLLH MLKR GALE GPFT HRPE PGTL KILP SYMS IYFD EPNP ARAK GSSP EGLP AWVL GELE TSEH KLNE SWKL SSGE DNTL VQSP TDVY SREQ YTGK LRVR SHSL SPTH REDG QNIT PKIC EVYS KKSP VSLD DSDI EARL NSWN LGIE NPRY LRQK PIPV SLMT PKFS LRKS
Gene ID:201134
Uniprot:Q8N8E3
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:24kDa/112kDa
Observed MW:113kDa
Synonyms:CEP112, CCDC46, MACOCO
Background:This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CCDC46: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: centrosome

NCBI Summary:This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:Q8N8E3
NCBI GenInfo Identifier:97045680
NCBI Gene ID:201134
NCBI Accession:Q8N8E3.2
UniProt Secondary Accession:Q8N8E3,Q6PIB5, Q8NCR4, Q8NFR4,
UniProt Related Accession:Q8N8E3
Molecular Weight:24,538 Da
NCBI Full Name:Centrosomal protein of 112 kDa
NCBI Synonym Full Names:centrosomal protein 112
NCBI Official Symbol:CEP112  
NCBI Official Synonym Symbols:CCDC46; MACOCO  
NCBI Protein Information:centrosomal protein of 112 kDa
UniProt Protein Name:Centrosomal protein of 112 kDa
UniProt Synonym Protein Names:Coiled-coil domain-containing protein 46
Protein Family:Centrosomal protein
UniProt Gene Name:CEP112  
UniProt Entry Name:CE112_HUMAN
Anti-CEP112 Antibody (CAB14302)Western blot analysis of extracts of various cell lines, using CEP112 antibody (CAB14302) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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