| Background: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. |
| UniProt Protein Function: | CELA3B: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.70; Protease Chromosomal Location of Human Ortholog: 1p36.12 Molecular Function:peptidase activity; serine-type endopeptidase activity Biological Process: cholesterol metabolic process; proteolysis |
| NCBI Summary: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009] |
| UniProt Code: | P08861 |
| NCBI GenInfo Identifier: | 317373457 |
| NCBI Gene ID: | 23436 |
| NCBI Accession: | P08861.3 |
| UniProt Secondary Accession: | P08861,P11423, Q5VU28, Q5VU29, Q5VU30, B2RE44, |
| UniProt Related Accession: | P08861 |
| Molecular Weight: | 29,263 Da |
| NCBI Full Name: | Chymotrypsin-like elastase family member 3B |
| NCBI Synonym Full Names: | chymotrypsin-like elastase family, member 3B |
| NCBI Official Symbol: | CELA3B |
| NCBI Official Synonym Symbols: | E1; CBPP; EL-1; ELA3B |
| NCBI Protein Information: | chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease |
| UniProt Protein Name: | Chymotrypsin-like elastase family member 3B |
| UniProt Synonym Protein Names: | Elastase IIIB; Elastase-3B; Protease E |
| Protein Family: | Chymotrypsin-like elastase family |
| UniProt Gene Name: | CELA3B |
| UniProt Entry Name: | CEL3B_HUMAN |
