Anti-CEL 항체 (CAB13011)

Antibody Name:	Anti-CEL Antibody
Antibody SKU:	CAB13011
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse pancreas

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human CEL (NP_001798.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	IDMP AINK GNKK VTEE DFYK LVSE FTIT KGLR GAKT TFDV YTES WAQD PSQE NKKK TVVD FETD VLFL VPTE IALA QHRA NAKS AKTY AYLF SHPS RMPV YPKW VGAD HADD IQYV FGKP FATP TGYR PQDR TVSK AMIA YWTN FAKT GDPN MGDS AVPT HWEP YTTE NSGY LEIT KKMG SSSM KRSL RTNF LRYW TLTY L
Gene ID:	1056
Uniprot:	P19835
Cellular Location:	Secreted
Calculated MW:	71kDa/79kDa
Observed MW:	67kDa

Synonyms:

CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8

Background:

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.

UniProt Protein Function:	CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Lipid Metabolism - glycerolipid; Lipid Metabolism - steroid biosynthesis; Secreted, signal peptide; EC 3.1.1.13; EC 3.1.1.3; Secreted; Lipase Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: extracellular space; cytoplasm; extracellular region Molecular Function:heparin binding; sterol esterase activity; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; fatty acid catabolic process; lipid metabolic process; protein amino acid esterification; pancreatic juice secretion; cholesterol catabolic process; lipid digestion Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction
NCBI Summary:	The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
UniProt Code:	P19835
NCBI GenInfo Identifier:	251757481
NCBI Gene ID:	1056
NCBI Accession:	P19835.3
UniProt Secondary Accession:	P19835,Q16398, Q5T7U7, Q9UCH1, Q9UP41,
UniProt Related Accession:	P19835
Molecular Weight:	71,834 Da
NCBI Full Name:	Bile salt-activated lipase
NCBI Synonym Full Names:	carboxyl ester lipase
NCBI Official Symbol:	CEL
NCBI Official Synonym Symbols:	BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
NCBI Protein Information:	bile salt-activated lipase; bile salt-dependent lipase, oncofetal isoform; bucelipase; carboxyl ester hydrolase; carboxyl ester lipase (bile salt-stimulated lipase); cholesterol esterase; fetoacinar pancreatic protein; lysophospholipase, pancreatic
UniProt Protein Name:	Bile salt-activated lipase
UniProt Synonym Protein Names:	Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase
Protein Family:	Bile salt-activated lipase
UniProt Gene Name:	CEL
UniProt Entry Name:	CEL_HUMAN

Western blot analysis of extracts of mouse pancreas, using CEL antibody (CAB13011) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

Anti-CEL Antibody (CAB7652)

CEL Antibody (PACO03352)

CEL Antibody (PACO08360)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)