Anti-CEACAM5 Antibody (CAB12421)

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SKU:
CAB12421
Product type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-CEACAM5 Antibody
Antibody SKU:CAB12421
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human CEACAM5
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Mouse
Positive Samples:Mouse pancreas
Immunogen:Recombinant protein of human CEACAM5
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1048
Uniprot:P06731
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:76kDa
Observed MW:150kDa
Synonyms:CEACAM5, CD66e, CEA
Background:This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function:identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis

NCBI Summary:Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
UniProt Code:P06731
NCBI GenInfo Identifier:317373456
NCBI Gene ID:1048
NCBI Accession:P06731.3
UniProt Secondary Accession:P06731,H9KVA7,
UniProt Related Accession:P06731
Molecular Weight:76,795 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Synonym Full Names:carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Official Symbol:CEACAM5  
NCBI Official Synonym Symbols:CEA; CD66e  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names:Carcinoembryonic antigen; CEA; Meconium antigen 100
Protein Family:Colicin
UniProt Gene Name:CEACAM5  
UniProt Entry Name:CEAM5_HUMAN
Anti-CEACAM5 Antibody (CAB12421)Western blot analysis of extracts of mouse pancreas, using CEACAM5 antibody (CAB12421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-CEACAM5 Antibody (CAB12421)Immunohistochemistry of paraffin-embedded mouse brain using CEACAM5 antibody (CAB12421) (40x lens).
Anti-CEACAM5 Antibody (CAB12421)Immunohistochemistry of paraffin-embedded mouse lung using CEACAM5 antibody (CAB12421) (40x lens).

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