Anti-CDS2 Antibody (CAB16080)
- SKU:
- CAB16080
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CDS2 Antibody |
| Antibody SKU: | CAB16080 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDS2 (NP_003809.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain, Mouse heart, Mouse kidney, Mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDS2 (NP_003809.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEL RQRV AHEP VAPP EDKE SESE AKVD GETA SDSE SRAE SAPL PVSA DDTP EVLN RALS NLSS RWKN WWVR GILT LAMI AFFF IIIY LGPM VLMI IVMC |
| Gene ID: | 8760 |
| Uniprot: | O95674 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 29kDa/51kDa |
| Observed MW: | 51kDa |
| Synonyms: | CDS2 |
| Background: | Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. |
| UniProt Protein Function: | CDS2: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. Belongs to the CDS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerophospholipid; Mitochondrial; Transferase; Membrane protein, multi-pass; Endoplasmic reticulum; EC 2.7.7.41; Membrane protein, integral Chromosomal Location of Human Ortholog: 20p13 Cellular Component: membrane; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane Molecular Function:phosphatidate cytidylyltransferase activity Biological Process: phosphatidylglycerol biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; CDP-diacylglycerol biosynthetic process |
| NCBI Summary: | Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95674 |
| NCBI GenInfo Identifier: | 7673965 |
| NCBI Gene ID: | 8760 |
| NCBI Accession: | O95674.1 |
| UniProt Secondary Accession: | O95674,Q99L43, |
| UniProt Related Accession: | O95674 |
| Molecular Weight: | 445 |
| NCBI Full Name: | Phosphatidate cytidylyltransferase 2 |
| NCBI Synonym Full Names: | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 |
| NCBI Official Symbol: | CDS2 |
| NCBI Protein Information: | phosphatidate cytidylyltransferase 2; CDS 2; CDP-DG synthase 2; CDP-DAG synthase 2; CDP-DG synthetase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride diphosphorylase 2; CDP-diglyceride pyrophosph |
| UniProt Protein Name: | Phosphatidate cytidylyltransferase 2 |
| UniProt Synonym Protein Names: | CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2 |
| Protein Family: | Phosphatidate cytidylyltransferase |
| UniProt Gene Name: | CDS2 |
| UniProt Entry Name: | CDS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDS2 antibody (CAB16080) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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