Anti-CDKN2D Antibody (CAB6556)
- SKU:
- CAB6556
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-CDKN2D Antibody |
| Antibody SKU: | CAB6556 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CDKN2D (NP_001791.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CDKN2D (NP_001791.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLLE EVRA GDRL SGAA ARGD VQEV RRLL HREL VHPD ALNR FGKT ALQV MMFG STAI ALEL LKQG ASPN VQDT SGTS PVHD AART GFLD TLKV LVEH GADV NVPD GTGA LPIH LAVQ EGHT AVVS FLAA ESDL HRRD ARGL TPLE LALQ RGAQ DLVD ILQG HMVA PL |
| Gene ID: | 1032 |
| Uniprot: | P55273 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 17kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CDKN2D, INK4D, p19, p19-INK4D |
| Background: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. |
| UniProt Protein Function: | CDKN2D: Interacts strongly with CDK4 and CDK6 and inhibits them. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. |
| UniProt Protein Details: | Protein type:Inhibitor; Cell cycle regulation; Tumor suppressor Chromosomal Location of Human Ortholog: 19p13 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding Biological Process: autophagic cell death; cell cycle arrest; DNA synthesis during DNA repair; G1/S transition of mitotic cell cycle; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; response to retinoic acid; response to UV; response to vitamin D |
| NCBI Summary: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55273 |
| NCBI GenInfo Identifier: | 1705730 |
| NCBI Gene ID: | 1032 |
| NCBI Accession: | P55273.1 |
| UniProt Secondary Accession: | P55273,Q13102, Q6FGE9, |
| UniProt Related Accession: | P55273 |
| Molecular Weight: | 17,700 Da |
| NCBI Full Name: | Cyclin-dependent kinase 4 inhibitor D |
| NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 2D |
| NCBI Official Symbol: | CDKN2D |
| NCBI Official Synonym Symbols: | p19; INK4D; p19-INK4D |
| NCBI Protein Information: | cyclin-dependent kinase 4 inhibitor D |
| UniProt Protein Name: | Cyclin-dependent kinase 4 inhibitor D |
| UniProt Synonym Protein Names: | p19-INK4d |
| Protein Family: | Cyclin-dependent kinase 4 inhibitor |
| UniProt Gene Name: | CDKN2D |
| UniProt Entry Name: | CDN2D_HUMAN |
 | Immunofluorescence analysis of NIH-3T3 cells using CDKN2D Rabbit pAb (CAB6556) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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