Anti-CDKN2C/p18-INK4C Antibody (CAB12418)
- SKU:
- CAB12418
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-CDKN2C/p18-INK4C Antibody |
| Antibody SKU: | CAB12418 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CDKN2C/p18-INK4C |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Raji, Mouse testis, Mouse spleen |
| Immunogen: | Recombinant protein of human CDKN2C/p18-INK4C |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1031 |
| Uniprot: | P42773 |
| Cellular Location: | |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | CDKN2C, INK4C, p18, p18-INK4C |
| Background: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. |
| UniProt Protein Function: | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| NCBI Summary: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42773 |
| NCBI GenInfo Identifier: | 1168870 |
| NCBI Gene ID: | 1031 |
| NCBI Accession: | P42773.1 |
| UniProt Secondary Accession: | P42773,Q8TB83, |
| UniProt Related Accession: | P42773 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | Cyclin-dependent kinase 4 inhibitor C |
| NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 2C |
| NCBI Official Symbol: | CDKN2C |
| NCBI Official Synonym Symbols: | p18; INK4C; p18-INK4C |
| NCBI Protein Information: | cyclin-dependent kinase 4 inhibitor C |
| UniProt Protein Name: | Cyclin-dependent kinase 4 inhibitor C |
| UniProt Synonym Protein Names: | Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6 |
| Protein Family: | Cyclin-dependent kinase 4 inhibitor |
| UniProt Gene Name: | CDKN2C |
 | Western blot analysis of extracts of various cell lines, using CDKN2C/p18-INK4C antibody (CAB12418) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using CDKN2C/p18-INK4C antibody (CAB12418) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using CDKN2C/p18-INK4C antibody (CAB12418) (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using CDKN2C/p18-INK4C antibody (CAB12418) (40x lens). |
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