Anti-CDK16 Antibody (CAB8140)
- SKU:
- CAB8140
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | CDK16 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8140 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-496 of human CDK16 (NP_006192.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-496 of human CDK16 (NP_006192.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CHRQ KVLH RDLK PQNL LINE RGEL KLAD FGLA RAKS IPTK TYSN EVVT LWYR PPDI LLGS TDYS TQID MWGV GCIF YEMA TGRP LFPG STVE EQLH FIFR ILGT PTEE TWPG ILSN EEFK TYNY PKYR AEAL LSHA PRLD SDGA DLLT KLLQ FEGR NRIS AEDA MKHP FFLS LGER IHKL PDTT SIFA LKEI QLQK EASL RSSS MPDS GRPA FRVV DTEF |
| Gene ID: | 5127 |
| Uniprot: | Q00536 |
| Cellular Location: | Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Peripheral membrane protein, secretory vesicle, synapse, synaptosome |
| Calculated MW: | 55kDa/56kDa/63kDa |
| Observed MW: | 56kDa |
| Synonyms: | CDK16, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 |
| Background: | The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CDK16: May play a role in signal transduction cascades in terminally differentiated cells. Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Cell cycle regulation; EC 2.7.11.22; Protein kinase, CMGC; Kinase, protein; CMGC group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily Chromosomal Location of Human Ortholog: Xp11 Cellular Component: microtubule cytoskeleton; synaptic vesicle; extrinsic to internal side of plasma membrane; neuron projection; transport vesicle; cytoplasm; plasma membrane; cell junction Molecular Function:protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding Biological Process: growth hormone secretion; exocytosis; regulation of cell cycle; spermatogenesis; protein amino acid phosphorylation; neurite development |
| NCBI Summary: | The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q00536 |
| NCBI GenInfo Identifier: | 266425 |
| NCBI Gene ID: | 5127 |
| NCBI Accession: | Q00536.1 |
| UniProt Secondary Accession: | Q00536,A8K280, B7Z7C8, J3KN74, J3KQP7, |
| UniProt Related Accession: | Q00536 |
| Molecular Weight: | 56,375 Da |
| NCBI Full Name: | Cyclin-dependent kinase 16 |
| NCBI Synonym Full Names: | cyclin-dependent kinase 16 |
| NCBI Official Symbol: | CDK16 |
| NCBI Official Synonym Symbols: | PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE |
| NCBI Protein Information: | cyclin-dependent kinase 16; PCTAIRE-motif protein kinase 1; cell division protein kinase 16; serine/threonine-protein kinase PCTAIRE-1 |
| UniProt Protein Name: | Cyclin-dependent kinase 16 |
| UniProt Synonym Protein Names: | Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1 |
| UniProt Gene Name: | CDK16 |
| UniProt Entry Name: | CDK16_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDK16 antibody (CAB8140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using CDK16 antibody (CAB8140) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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