Anti-CDK11B Antibody (CAB14715)

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SKU:
CAB14715
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-CDK11B Antibody
Antibody SKU:CAB14715
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGDE KDSW KVKT LDEI LQEK KRRK EQEE KAEI KRLK NSDD RDSK RDSL EEGE LRDH RMEI TIRN SPYR REDS MEDR GEED DSLA IKPP QQMS RKEK AHHR KDEK RKEK RRHR SHSA EGGK HARV KEKE RE
Gene ID:984
Uniprot:P21127
Cellular Location:Cytoplasm, Nucleus
Calculated MW:49-92kDa
Observed MW:
Synonyms:CDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1
Background:This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
NCBI Summary:This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Code:P21127
NCBI GenInfo Identifier:34978359
NCBI Gene ID:984
NCBI Accession:P21127.3
UniProt Secondary Accession:P21127,O95265, Q12817, Q12818, Q12819, Q12820, Q12822 Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0,
UniProt Related Accession:P21127
Molecular Weight:49,555 Da
NCBI Full Name:Cyclin-dependent kinase 11B
NCBI Synonym Full Names:cyclin-dependent kinase 11B
NCBI Official Symbol:CDK11B  
NCBI Official Synonym Symbols:p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110  
NCBI Protein Information:cyclin-dependent kinase 11B
UniProt Protein Name:Cyclin-dependent kinase 11B
UniProt Synonym Protein Names:Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1
Protein Family:Cyclin-dependent kinase
UniProt Gene Name:CDK11B  
UniProt Entry Name:CD11B_HUMAN
Anti-CDK11B Antibody (CAB14715)Immunofluorescence analysis of HeLa cells using CDK11B antibody (CAB14715) at dilution of 1:100. Blue: DAPI for nuclear staining.

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