Anti-CDK11B Antibody (CAB12830)
- SKU:
- CAB12830
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-CDK11B Antibody |
| Antibody SKU: | CAB12830 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDE KDSW KVKT LDEI LQEK KRRK EQEE KAEI KRLK NSDD RDSK RDSL EEGE LRDH RMEI TIRN SPYR REDS MEDR GEED DSLA IKPP QQMS RKEK AHHR KDEK RKEK RRHR SHSA EGGK HARV KEKE RE |
| Gene ID: | 984 |
| Uniprot: | P21127 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 49-92kDa |
| Observed MW: | 110kDa |
| Synonyms: | CDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1 |
| Background: | This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| NCBI Summary: | This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P21127 |
| NCBI GenInfo Identifier: | 34978359 |
| NCBI Gene ID: | 984 |
| NCBI Accession: | P21127.3 |
| UniProt Secondary Accession: | P21127,O95265, Q12817, Q12818, Q12819, Q12820, Q12822 Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, |
| UniProt Related Accession: | P21127 |
| Molecular Weight: | 49,555 Da |
| NCBI Full Name: | Cyclin-dependent kinase 11B |
| NCBI Synonym Full Names: | cyclin-dependent kinase 11B |
| NCBI Official Symbol: | CDK11B |
| NCBI Official Synonym Symbols: | p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110 |
| NCBI Protein Information: | cyclin-dependent kinase 11B |
| UniProt Protein Name: | Cyclin-dependent kinase 11B |
| UniProt Synonym Protein Names: | Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1 |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK11B |
| UniProt Entry Name: | CD11B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDK11B Antibody (CAB12830) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using CDK11B antibody (CAB12830) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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