Anti-CDC16 Antibody (CAB3583)

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SKU:
CAB3583
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ANAPC6
APC6
CDC16Hs
CUT9
Frequently bought together:

Description

Product Name:CDC16 Rabbit mAb
Product Code:CAB3583
Size:20uL, 50uL, 100uL
Synonyms:ANAPC6, APC6, CDC16Hs, CUT9
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CDC16
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:NIH/3T3
Immunogen:A synthesized peptide derived from human CDC16
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8881
Uniprot:Q13042
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:72kDa
Observed MW:72kDa
UniProt Protein Function:CDC16: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; cytosol

Molecular Function:protein binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell proliferation; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; regulation of mitosis; mitotic cell cycle

NCBI Summary:This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q13042
NCBI GenInfo Identifier:37537763
NCBI Gene ID:8881
NCBI Accession:Q13042.2
UniProt Secondary Accession:Q13042,Q5T8C8, Q7Z651, Q96AE6, Q9Y564, A2A365,
UniProt Related Accession:Q13042
Molecular Weight:620
NCBI Full Name:Cell division cycle protein 16 homolog
NCBI Synonym Full Names:cell division cycle 16
NCBI Official Symbol:CDC16  
NCBI Official Synonym Symbols:APC6; CUT9; ANAPC6  
NCBI Protein Information:cell division cycle protein 16 homolog; CDC16Hs; cyclosome subunit 6; cell division cycle 16 homolog; anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6
UniProt Protein Name:Cell division cycle protein 16 homolog
UniProt Synonym Protein Names:Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6
Protein Family:Cell division control protein
UniProt Gene Name:CDC16  
UniProt Entry Name:CDC16_HUMAN

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