Anti-CD8A Antibody,PE Conjugated (MACO0316)
- SKU:
- MACO0316
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- IF
- Application:
- FC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
| Product Name: | Anti-CD8A Antibody,PE Conjugated |
| Product Sku: | MACO0316 |
| Size: | 100ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IF, FC |
| Recommended Dilutions: | IF:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Protein |
| Form: | Liquid |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Purification Method: | Affinity purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.* Ratio of CD4 and CD8 is important for monitor of HIV infection.1. Engleman EG et al. (1981) J Exp Med 153: 193-198.2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science 274:1906. |
| Synonyms: |
| UniProt Protein Function: | Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
| UniProt Protein Details: | Subunit structure: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. Ref.9 Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Post-translational modification: All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not By similarity. Involvement in Disease: CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.Note: The disease is caused by mutations affecting the gene represented in this entry. Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| NCBI Summary: | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | P01732 |
| NCBI GenInfo Identifier: | 116035 |
| NCBI Gene ID: | 925 |
| NCBI Accession: | P01732.1 |
| UniProt Secondary Accession: | P01732,Q13970, Q4ZG17, D6W5M8, |
| UniProt Related Accession: | P01732 |
| Molecular Weight: | |
| NCBI Full Name: | T-cell surface glycoprotein CD8 alpha chain |
| NCBI Synonym Full Names: | CD8a molecule |
| NCBI Official Symbol: | CD8A |
| NCBI Official Synonym Symbols: | CD8; MAL; p32; Leu2 |
| NCBI Protein Information: | T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2 |
| UniProt Protein Name: | T-cell surface glycoprotein CD8 alpha chain |
| UniProt Synonym Protein Names: | T-lymphocyte differentiation antigen T8/Leu-2 |
| Protein Family: | CD81 antigen |
| UniProt Gene Name: | CD8A |
| UniProt Entry Name: | CD8A_HUMAN |
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