Anti-CD58 Antibody (CAB5684)
- SKU:
- CAB5684
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CD58 Antibody |
| Antibody SKU: | CAB5684 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-220 of human CD58 (NP_001770.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-220 of human CD58 (NP_001770.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NVTF HVPS NVPL KEVL WKKQ KDKV AELE NSEF RAFS SFKN RVYL DTVS GSLT IYNL TSSD EDEY EMES PNIT DTMK FFLY VLES LPSP TLTC ALTN GSIE VQCM IPEH YNSH RGLI MYSW DCPM EQCK RNST SIYF KMEN DLPQ KIQC TLSN PLFN TTSS IILT TCIP SSGH SRHR YALI P |
| Gene ID: | 965 |
| Uniprot: | P19256 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Single-pass type I membrane protein |
| Calculated MW: | 26kDa/27kDa/28kDa |
| Observed MW: | 70kDa |
| Synonyms: | CD58, LFA-3, LFA3, ag3 |
| Background: | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
| NCBI Summary: | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P19256 |
| NCBI GenInfo Identifier: | 126225 |
| NCBI Gene ID: | 965 |
| NCBI Accession: | P19256.1 |
| UniProt Secondary Accession: | P19256,Q5U053, Q6IB65, Q96KI9, A8K7G5, |
| UniProt Related Accession: | P19256 |
| Molecular Weight: | 27,960 Da |
| NCBI Full Name: | Lymphocyte function-associated antigen 3 |
| NCBI Synonym Full Names: | CD58 molecule |
| NCBI Official Symbol: | CD58 |
| NCBI Official Synonym Symbols: | ag3; LFA3; LFA-3 |
| NCBI Protein Information: | lymphocyte function-associated antigen 3 |
| UniProt Protein Name: | Lymphocyte function-associated antigen 3 |
| UniProt Synonym Protein Names: | Surface glycoprotein LFA-3; CD_antigen: CD58 |
| Protein Family: | Lymphocyte function-associated antigen |
| UniProt Gene Name: | CD58 |
 | Western blot analysis of extracts of various cell lines, using CD58 Antibody (CAB5684) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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