Anti-CD53 Antibody (CAB10079)
- SKU:
- CAB10079
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CD53 Antibody |
| Antibody SKU: | CAB10079 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human CD53 (NP_000551.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | B cells, Jurkat, Raji, HL-60, Mouse liver, Mouse spleen, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human CD53 (NP_000551.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AILL FVYE QKLN EYVA KGLT DSIH RYHS DNST KAAW DSIQ SFLQ CCGI NGTS DWTS GPPA SCPS DRKV EGCY AKAR LWFH S |
| Gene ID: | 963 |
| Uniprot: | P19397 |
| Cellular Location: | Cell junction, Cell membrane, Membrane, Multi-pass membrane protein |
| Calculated MW: | 24kDa |
| Observed MW: | 35kDa |
| Synonyms: | CD53, MOX44, TSPAN25 |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CD53: May be involved in growth regulation in hematopoietic cells. Belongs to the tetraspanin (TM4SF) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p13 Cellular Component: cell surface; plasma membrane; integral to membrane; immunological synapse; intercellular junction Molecular Function:protein binding Biological Process: signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P19397 |
| NCBI GenInfo Identifier: | 10834972 |
| NCBI Gene ID: | 963 |
| NCBI Accession: | NP_000551.1 |
| UniProt Related Accession: | P19397 |
| Molecular Weight: | |
| NCBI Full Name: | leukocyte surface antigen CD53 isoform 1 |
| NCBI Synonym Full Names: | CD53 molecule |
| NCBI Official Symbol: | CD53 |
| NCBI Official Synonym Symbols: | MOX44; TSPAN25 |
| NCBI Protein Information: | leukocyte surface antigen CD53 |
| UniProt Protein Name: | Leukocyte surface antigen CD53 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein CD53; Tetraspanin-25; Tspan-25; CD_antigen: CD53 |
| Protein Family: | Leukocyte surface antigen |
| UniProt Gene Name: | CD53 |
| UniProt Entry Name: | CD53_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD53 antibody (CAB10079) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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