| UniProt Protein Function: | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. |
| NCBI Summary: | The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09693 |
| NCBI GenInfo Identifier: | 115993 |
| NCBI Gene ID: | 917 |
| NCBI Accession: | P09693.1 |
| UniProt Secondary Accession: | P09693,Q2HIZ6, |
| UniProt Related Accession: | P09693 |
| Molecular Weight: | 20,469 Da |
| NCBI Full Name: | T-cell surface glycoprotein CD3 gamma chain |
| NCBI Synonym Full Names: | CD3g molecule |
| NCBI Official Symbol: | CD3G |
| NCBI Official Synonym Symbols: | T3G; IMD17; CD3-GAMMA |
| NCBI Protein Information: | T-cell surface glycoprotein CD3 gamma chain |
| UniProt Protein Name: | T-cell surface glycoprotein CD3 gamma chain |
| UniProt Synonym Protein Names: | T-cell receptor T3 gamma chain; CD_antigen: CD3g |
| Protein Family: | T-cell surface glycoprotein |
| UniProt Gene Name: | CD3G |
