Anti-CD38 Antibody (CAB13611)
- SKU:
- CAB13611
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CD38 Antibody |
| Antibody SKU: | CAB13611 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 46-300 of human CD38 (NP_001766.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 46-300 of human CD38 (NP_001766.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WRQQ WSGP GTTK RFPE TVLA RCVK YTEI HPEM RHVD CQSV WDAF KGAF ISKH PCNI TEED YQPL MKLG TQTV PCNK ILLW SRIK DLAH QFTQ VQRD MFTL EDTL LGYL ADDL TWCG EFNT SKIN YQSC PDWR KDCS NNPV SVFW KTVS RRFA EAAC DVVH VMLN GSRS KIFD KNST FGSV EVHN LQPE KVQT LEAW VIHG GRED SRDL CQDP TIKE LESI ISKR NIQF SCKN IYRP DKFL QCVK NPED SSCT SEI |
| Gene ID: | 952 |
| Uniprot: | P28907 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 13kDa/34kDa |
| Observed MW: | 42kDa |
| Synonyms: | CD38, ADPRC 1, ADPRC1 |
| Background: | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation Chromosomal Location of Human Ortholog: 4p15 Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus Molecular Function:transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis |
| NCBI Summary: | CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28907 |
| NCBI GenInfo Identifier: | 55977782 |
| NCBI Gene ID: | 952 |
| NCBI Accession: | P28907.2 |
| UniProt Secondary Accession: | P28907,O00121, O00122, Q96HY4, |
| UniProt Related Accession: | P28907 |
| Molecular Weight: | 300 |
| NCBI Full Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| NCBI Synonym Full Names: | CD38 molecule |
| NCBI Official Symbol: | CD38 |
| NCBI Official Synonym Symbols: | T10; ADPRC 1 |
| NCBI Protein Information: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase |
| UniProt Protein Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| UniProt Synonym Protein Names: | 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38 |
| Protein Family: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
| UniProt Gene Name: | CD38 |
| UniProt Entry Name: | CD38_HUMAN |
 | Western blot analysis of extracts of Raji cells, using CD38 Antibody (CAB13611) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon using CD38 antibody (CAB13611) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of THP-1 cells using CD38 Rabbit pAb (CAB13611) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of rat spleen using CD38 Rabbit pAb (CAB13611) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse spleen using CD38 Rabbit pAb (CAB13611) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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