Anti-CD31/PECAM1 Antibody (CAB0378)

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SKU:
CAB0378
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CD31/PECAM1 Antibody
Antibody SKU:CAB0378
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of mouse CD31/PECAM1 (NP_001292086.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of mouse CD31/PECAM1 (NP_001292086.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:18613
Uniprot:Q08481
Cellular Location:Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein
Calculated MW:79kDa/80kDa/81kDa/82kDa
Observed MW:130kDa
Synonyms:PECAM1, CD31, CD31/EndoCAM, GPIIA, PECA1, PECAM-1, endoCAM
Background:The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
UniProt Protein Function:PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Cellular Component: extracellular space; cell surface; smooth muscle contractile fiber; membrane; integral to membrane; plasma membrane; intracellular; cell junction; lipid raft; external side of plasma membrane

Molecular Function:protein binding

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; wound healing; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of actin filament polymerization; positive regulation of leukocyte migration; diapedesis; cell adhesion; regulation of cell migration; phagocytosis; Rho protein signal transduction

UniProt Code:Q08481
NCBI GenInfo Identifier:585658
NCBI Gene ID:18613
NCBI Accession:Q08481.1
UniProt Related Accession:Q08481
Molecular Weight:
NCBI Full Name:Platelet endothelial cell adhesion molecule
NCBI Synonym Full Names:platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol:Pecam1  
NCBI Official Synonym Symbols:Cd31; Pecam; C85791; PECAM-1  
NCBI Protein Information:platelet endothelial cell adhesion molecule
UniProt Protein Name:Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names:CD_antigen: CD31
UniProt Gene Name:Pecam1  
UniProt Entry Name:PECA1_MOUSE
Anti-CD31/PECAM1 Antibody (CAB0378)Western blot analysis of extracts of mouse liver, using CD31/PECAM1 antibody (CAB0378) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CD31/PECAM1 Antibody (CAB0378)Immunohistochemistry of paraffin-embedded Human placenta using CD31/PECAM1 Rabbit pAb (CAB0378) at dilution of 1:100 (40x lens).

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