Anti-CD2BP2 Antibody (CAB15777)

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SKU:
CAB15777
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-CD2BP2 Antibody
Antibody SKU:CAB15777
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CD2BP2 (NP_006101.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, 293T, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CD2BP2 (NP_006101.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPKR KVTF QGVG DEED EDEI IVPK KKLV DPVA GSGG PGSR FKGK HSLD SDEE EDDD DGGS SKYD ILAS EDVE GQEA ATLP SEGG VRIT PFNL QEEM EEGH FDAD GNYF LNRD AQIR DSWL DNID WVKI RERP PGQR QASD SEEE DSLG QTSM SAQA LLEG LLEL LLPR ETVA GALR RLGA RGGG KGRK GPGQ PSSP QRLD RLSG LADQ MVAR GNLG VYQE TRER LAMR LKGL GCQT LGPH NPTP PPSL DMFA EELA EEEL ETPT PTQR GEAE SRGD GLVD VMWE YKWE NTGD AELY GPFT SAQM QTWV SEGY FPDG VYCR KLDP PGGQ FYNS KRID FDLY T
Gene ID:10421
Uniprot:O95400
Cellular Location:Cytoplasm, Nucleus
Calculated MW:37kDa
Observed MW:54kDa
Synonyms:CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K
Background:This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
UniProt Protein Function:CD2BP2: Binds the cytoplasmic domain of CD2 through the GYF domain.
UniProt Protein Details:

Protein type:RNA processing; Adaptor/scaffold; Spliceosome

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; snRNP U5; U4/U6 x U5 tri-snRNP complex

Molecular Function:protein binding; ribonucleoprotein binding

Biological Process: nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
UniProt Code:O95400
NCBI GenInfo Identifier:31339956
NCBI Gene ID:10421
NCBI Accession:O95400.1
UniProt Secondary Accession:O95400,Q9ULP2, B2RDX2,
UniProt Related Accession:O95400
Molecular Weight:37,646 Da
NCBI Full Name:CD2 antigen cytoplasmic tail-binding protein 2
NCBI Synonym Full Names:CD2 cytoplasmic tail binding protein 2
NCBI Official Symbol:CD2BP2  
NCBI Official Synonym Symbols:LIN1; Snu40; FWP010; U5-52K; PPP1R59  
NCBI Protein Information:CD2 antigen cytoplasmic tail-binding protein 2
UniProt Protein Name:CD2 antigen cytoplasmic tail-binding protein 2
UniProt Synonym Protein Names:U5 snRNP 52K protein; U5-52K
Protein Family:CD2 antigen cytoplasmic tail-binding protein
UniProt Gene Name:CD2BP2  
UniProt Entry Name:CD2B2_HUMAN
Anti-CD2BP2 Antibody (CAB15777)Western blot analysis of extracts of various cell lines, using CD2BP2 antibody (CAB15777) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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