Anti-CD20 Antibody (CAB1793)
- SKU:
- CAB1793
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-CD20 Antibody |
| Antibody SKU: | CAB1793 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 208-297 of human CD20 (NP_068769.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | COS-7, H125, Mouse thymus, Mouse liver, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 208-297 of human CD20 (NP_068769.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IAGI VENE WKRT CSRP KSNI VLLS AEEK KEQT IEIK EEVV GLTE TSSQ PKNE EDIE IIPI QEEE EEET ETNF PEPP QDQE SSPI ENDS SP |
| Gene ID: | 931 |
| Uniprot: | P11836 |
| Cellular Location: | Cell membrane, Lipid-anchor, Multi-pass membrane protein |
| Calculated MW: | 14kDa/33kDa |
| Observed MW: | 37kDa |
| Synonyms: | MS4A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7 |
| Background: | This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. |
| UniProt Protein Function: | MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q12 Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane Molecular Function:epidermal growth factor receptor binding Biological Process: B cell proliferation; humoral immune response Disease: Immunodeficiency, Common Variable, 5 |
| NCBI Summary: | This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11836 |
| NCBI GenInfo Identifier: | 115968 |
| NCBI Gene ID: | 931 |
| NCBI Accession: | P11836.1 |
| UniProt Related Accession: | P11836 |
| Molecular Weight: | |
| NCBI Full Name: | B-lymphocyte antigen CD20 |
| NCBI Synonym Full Names: | membrane spanning 4-domains A1 |
| NCBI Official Symbol: | MS4A1 |
| NCBI Official Synonym Symbols: | B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16 |
| NCBI Protein Information: | B-lymphocyte antigen CD20 |
| UniProt Protein Name: | B-lymphocyte antigen CD20 |
| UniProt Synonym Protein Names: | B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20 |
| Protein Family: | CD209 antigen |
| UniProt Gene Name: | MS4A1 |
| UniProt Entry Name: | CD20_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD20 Antibody (CAB1793) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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