Anti-CD18 Antibody (CAB19012)

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SKU:
CAB19012
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CD18 Antibody
Antibody SKU:CAB19012
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD18
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-937
Immunogen:A synthesized peptide derived from human CD18
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3689
Uniprot:P05107
Cellular Location:
Calculated MW:95kDa
Observed MW:100kDa
Anti-CD18 Antibody (CAB19012)Western blot - CD18 Rabbit mAb (CAB19012)
Synonyms:CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, ITGB2
Background:This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Protein Function:ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Cell surface; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft

Molecular Function:protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; toll-like receptor 4 signaling pathway; regulation of peptidyl-tyrosine phosphorylation; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; innate immune response; endothelial cell migration; blood coagulation; leukocyte migration

Disease: Leukocyte Adhesion Deficiency, Type I

NCBI Summary:This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:P05107
NCBI GenInfo Identifier:124056465
NCBI Gene ID:3689
NCBI Accession:P05107.2
UniProt Secondary Accession:P05107,Q16418, Q53HS5, Q9UD72, B3KTS8, D3DSM1,
UniProt Related Accession:P05107
Molecular Weight:769
NCBI Full Name:Integrin beta-2
NCBI Synonym Full Names:integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCBI Official Symbol:ITGB2  
NCBI Official Synonym Symbols:LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1  
NCBI Protein Information:integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)
UniProt Protein Name:Integrin beta-2
UniProt Synonym Protein Names:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
Protein Family:Integrin
UniProt Gene Name:ITGB2  
UniProt Entry Name:ITB2_HUMAN

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