Anti-CD168[KO Validated] Antibody (CAB11666)

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SKU:
CAB11666
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-CD168[KO Validated] Antibody
Antibody SKU:CAB11666
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD168
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, K-562
Immunogen:A synthesized peptide derived from human CD168
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3161
Uniprot:O75330
Cellular Location:Cell surface, Cytoplasm
Calculated MW:85kDa
Observed MW:84KDa
Anti-CD168[KO Validated] AntibodyWestern blot analysis of extracts from normal (control) and CD168 knockout (KO) HeLa cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
Anti-CD168[KO Validated] AntibodyWestern blot analysis of extracts of K-562 cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
Anti-CD168[KO Validated] AntibodyImmunohistochemistry of paraffin-embedded mouse kidney using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens).
Anti-CD168[KO Validated] AntibodyImmunohistochemistry of paraffin-embedded human esophageal using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens).
Synonyms:CD168, IHABP, RHAMM
Background:The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
UniProt Protein Function:HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cell surface; membrane; cytoplasm; plasma membrane

Molecular Function:hyaluronic acid binding

Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process

Disease: Breast Cancer

NCBI Summary:The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:O75330
NCBI GenInfo Identifier:145559482
NCBI Gene ID:3161
NCBI Accession:O75330.2
UniProt Secondary Accession:O75330,Q32N02, Q92767, A8K3G2, B4E114, D3DQK9, D3DQL0 E9PCS0,
UniProt Related Accession:O75330
Molecular Weight:
NCBI Full Name:Hyaluronan mediated motility receptor
NCBI Synonym Full Names:hyaluronan-mediated motility receptor (RHAMM)
NCBI Official Symbol:HMMR  
NCBI Official Synonym Symbols:CD168; IHABP; RHAMM  
NCBI Protein Information:hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein
UniProt Protein Name:Hyaluronan mediated motility receptor
UniProt Synonym Protein Names:Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168
Protein Family:Hyaluronan mediated motility receptor
UniProt Gene Name:HMMR  
UniProt Entry Name:HMMR_HUMAN

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