Anti-CD163 Antibody (CAB8383)
- SKU:
- CAB8383
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-CD163 Antibody |
| Antibody SKU: | CAB8383 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-1050 of human CD163 (NP_004235.4). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-1050 of human CD163 (NP_004235.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSDA HVVC RQLG CGEA INAT GSAH FGEG TGPI WLDE MKCN GKES RIWQ CHSH GWGQ QNCR HKED AGVI CSEF MSLR LTSE ASRE ACAG RLEV FYNG AWGT VGKS SMSE TTVG VVCR QLGC ADKG KINP ASLD KAMS IPMW VDNV QCPK GPDT LWQC PSSP WEKR LASP SEET WITC DNKI RLQE GPTS CSGR VEIW HGGS WGTV CDDS WDLD DAQV VCQQ LGCG PALK AFKE AEFG QGTG PIWL NEVK CKGN ESSL WDCP ARRW GHSE CGHK EDAA VNCT DISV QKTP QKAT TGRS SRQS S |
| Gene ID: | 9332 |
| Uniprot: | Q86VB7 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 121kDa/124kDa/125kDa |
| Observed MW: | 160kDa |
| Synonyms: | CD163, M130, MM130, SCARI1 |
| Background: | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| NCBI Summary: | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q86VB7 |
| NCBI GenInfo Identifier: | 313104083 |
| NCBI Gene ID: | 9332 |
| NCBI Accession: | |
| UniProt Related Accession: | Q86VB7 |
| Molecular Weight: | |
| NCBI Full Name: | Scavenger receptor cysteine-rich type 1 protein M130 |
| NCBI Synonym Full Names: | CD163 molecule |
| NCBI Official Symbol: | CD163 |
| NCBI Official Synonym Symbols: | M130; MM130; SCARI1 |
| NCBI Protein Information: | scavenger receptor cysteine-rich type 1 protein M130 |
| UniProt Protein Name: | |
| Protein Family: | Scavenger receptor cysteine-rich type 1 protein |
| UniProt Gene Name: |
 | Western blot analysis of extracts of various cell lines, using CD163 antibody (CAB8383) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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