Anti-CD160 antigen Antibody (CAB8189)
- SKU:
- CAB8189
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | CD160 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8189 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, HT-29, U-937, Raji, Mouse spleen, Mouse small intestine, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLLE PGRG CCAL AILL AIVD IQSG GCIN ITSS ASQE GTRL NLIC TVWH KKEE AEGF VVFL CKDR SGDC SPET SLKQ LRLK RDPG IDGV GEIS SQLM FTIS QVTP LHSG TYQC CARS QKSG IRLQ GHFF SILF TETG NYTV TGLK QRQH LEFS HNEG TLSS GFLQ EKVW VMLV TSLV ALQA L |
| Gene ID: | 11126 |
| Uniprot: | O95971 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 19kDa |
| Observed MW: | 20kDa |
| Synonyms: | CD160, BY55, NK1, NK28 |
| Background: | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. |
| UniProt Protein Function: | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. |
| NCBI Summary: | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95971 |
| NCBI GenInfo Identifier: | 17372903 |
| NCBI Gene ID: | 11126 |
| NCBI Accession: | O95971.1 |
| UniProt Related Accession: | O95971 |
| Molecular Weight: | 19,810 Da |
| NCBI Full Name: | CD160 antigen |
| NCBI Synonym Full Names: | CD160 molecule |
| NCBI Official Symbol: | CD160 |
| NCBI Official Synonym Symbols: | NK1; BY55; NK28 |
| NCBI Protein Information: | CD160 antigen |
| UniProt Protein Name: | CD160 antigen |
| UniProt Synonym Protein Names: | Natural killer cell receptor BY55; CD_antigen: CD160 |
| Protein Family: | CD160 antigen |
| UniProt Gene Name: | CD160 |
 | Western blot analysis of extracts of various cell lines, using CD160 antibody (CAB8189) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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