Anti-CD14 Antibody,PE-Cy5 Conjugated (MACO0266)
- SKU:
- MACO0266
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- IF
- Application:
- FC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | Anti-CD14 Antibody,PE-Cy5 Conjugated |
| Product Sku: | MACO0266 |
| Size: | 100ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IF, FC |
| Recommended Dilutions: | IF:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Protein |
| Form: | Liquid |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Purification Method: | Affinity purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | 4AW4 reacts with CD14, a 53-55 kDa molecule. CD14 is a human high affinity cell-surface receptor for complexes of lipopolysaccharide (LPS-endotoxin) and serum LPS-binding protein (LPB). CD14 antigen has a strong presence on the surface of monocytes/macrophages, is weakly expressed on granulocytes, but not expressed by myeloid progenitor cells. CD14 functions as a receptor for endotoxin; when the monocytes become activated they release cytokines such as TNF, and up-regulate cell surface molecules including adhesion molecules.This clone is cross reactive with non-human primate.1. Knapp, W et al., eds. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.2. Makgoba, MW et al., (1988) Nature 331: 86-883. Boyd. AW et al. (1989) Blood 73: 1896-1903 |
| Synonyms: |
| UniProt Protein Function: | CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Cellular Component: anchored to external side of plasma membrane; extracellular space; cell surface; membrane; plasma membrane; lipopolysaccharide receptor complex; lipid raft; external side of plasma membrane Molecular Function:lipopolysaccharide binding Biological Process: response to bacterium; immune system process; response to molecule of bacterial origin; innate immune response; positive regulation of endocytosis; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of cytokine secretion |
| NCBI Summary: | This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P08571 |
| NCBI GenInfo Identifier: | 6753332 |
| NCBI Gene ID: | 12475 |
| NCBI Accession: | NP_033971.1 |
| UniProt Related Accession: | P10810 |
| Molecular Weight: | |
| NCBI Full Name: | monocyte differentiation antigen CD14 |
| NCBI Synonym Full Names: | CD14 antigen |
| NCBI Official Symbol: | Cd14 |
| NCBI Protein Information: | monocyte differentiation antigen CD14 |
| UniProt Protein Name: | Monocyte differentiation antigen CD14 |
| UniProt Synonym Protein Names: | Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14 |
| Protein Family: | Monocyte differentiation antigen |
| UniProt Gene Name: | Cd14 |
| UniProt Entry Name: | CD14_MOUSE |
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