Anti-CCR6 Antibody (CAB16206)
- SKU:
- CAB16206
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-CCR6 Antibody |
| Antibody SKU: | CAB16206 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CCR6 (NP_004358.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CCR6 (NP_004358.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VTEV LAFL HCCL NPVL YAFI GQKF RNYF LKIL KDLW CVRR KYKS SGFS CAGR YSEN ISRQ TSET ADND NASS FTM |
| Gene ID: | 1235 |
| Uniprot: | P51684 |
| Cellular Location: | |
| Calculated MW: | 42kDa |
| Observed MW: | 52kDa |
| Synonyms: | CCR6, BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 |
| Background: | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. |
| UniProt Protein Function: | CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q27 Cellular Component: cell surface; cytosol; integral to plasma membrane; plasma membrane Molecular Function:C-C chemokine receptor activity; chemokine receptor activity; receptor activity Biological Process: cell motility; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; humoral immune response; immune response; innate immune response; signal transduction |
| NCBI Summary: | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51684 |
| NCBI GenInfo Identifier: | 2851567 |
| NCBI Gene ID: | 1235 |
| NCBI Accession: | P51684.2 |
| UniProt Secondary Accession: | P51684,P78553, Q92846, E1P5C6, |
| UniProt Related Accession: | P51684 |
| Molecular Weight: | 42,494 Da |
| NCBI Full Name: | C-C chemokine receptor type 6 |
| NCBI Synonym Full Names: | C-C motif chemokine receptor 6 |
| NCBI Official Symbol: | CCR6 |
| NCBI Official Synonym Symbols: | BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6 |
| NCBI Protein Information: | C-C chemokine receptor type 6 |
| UniProt Protein Name: | C-C chemokine receptor type 6 |
| UniProt Synonym Protein Names: | Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor; CD_antigen: CD196 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR6 |
| UniProt Entry Name: | CCR6_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using CCR6 antibody (CAB16206) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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