Anti-CCR2/CKR2 Antibody (CAB2385)
- SKU:
- CAB2385
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CCR2
- CC-CKR-2
- CCR-2
- CCR2A
- CCR2B
- CD192
- CKR2
- CKR2A
- CKR2B
- CMKBR2
- MCP-1-R
- C-C chemokine receptor type 2
Description
| Product Name: | CCR2/CKR2 Rabbit mAb |
| Product Code: | CAB2385 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C chemokine receptor type 2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CCR2/CKR2. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, U-937, Mouse lung, Rat lung |
| Immunogen: | A synthesized peptide derived from human CCR2/CKR2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 729230 |
| Uniprot: | P41597 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | kDa |
| Observed MW: | 42KDa |
| UniProt Protein Function: | CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cell soma; integral to plasma membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol Molecular Function:protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; innate immune response; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of inflammatory response |
| NCBI Summary: | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P41597 |
| NCBI GenInfo Identifier: | 1168965 |
| NCBI Gene ID: | 729230 |
| NCBI Accession: | P41597.1 |
| UniProt Secondary Accession: | P41597,Q4VBL2, A0AVQ3, B2RMT0, |
| UniProt Related Accession: | P41597 |
| Molecular Weight: | 41,064 Da |
| NCBI Full Name: | C-C chemokine receptor type 2 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 2 |
| NCBI Official Symbol: | CCR2 |
| NCBI Official Synonym Symbols: | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 |
| NCBI Protein Information: | C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor |
| UniProt Protein Name: | C-C chemokine receptor type 2 |
| UniProt Synonym Protein Names: | Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR2 |
| UniProt Entry Name: | CCR2_HUMAN |
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